Chemotherapy dosage: personalised treatment for cancer patients

In an oncology protocol and chemotherapy dosage, each micro-variation can compromise the targeted destruction of cancer cells and the outcome of chemotherapy treatment for various solid cancers.
From the dose calculated based on the body surface area of ​​cancer patients to the final dilution, each step directly influences therapeutic efficacy and patient safety. Icones Services provides hospital pharmacies with the analytical precision of QCRx® to secure the administration of anticancer drugs.

Risks of inaccurate dosage

Risks (hematological toxicity, bone marrow damage) linked to inaccurate dosage

Even before administration, the slightest shift in concentration can tip the risk-benefit balance. In concrete terms, even a small deviation leads to two opposing, but equally critical, scenarios:
  • Underdose: Reduced tumor cell destruction and decreased overall survival.
  • Overdose: Serious side effects (nausea, hand-foot syndrome), and even death.

QCRx®: Real-time cytotoxic analysis

To eliminate this uncertainty factor, the QCRx® guarantees the quality of the chemotherapy dose even for sensitive molecules thanks to its automation technology and dual UV-Vis / Raman spectrometry to control, in a few seconds, the conformity of each cytotoxic preparation without interrupting the production flow.

The QCRx® allows accurately detecting deviations between the measured concentration and the dose calculated according to the prescribed body surface area, with an average threshold of ± 0.1%. If this threshold is exceeded, particularly for sensitive molecules such as epidermal growth factor receptor (EGFR) inhibitors, the preparation in question is immediately blocked.

This precision, coupled with the instant traceability of UV/Raman spectra, eliminates the uncertainty linked to chemotherapy dosage and secures the treatment of the oncology patient.

See the QCRx® in action.

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Compliance and traceability

Accuracy is only valuable if it is demonstrable. The ANSM’s Good Preparation Practices (GPP 2023) require that each prepared batch be the subject of a time-stamped and signed certificate kept for any inspection. For its part, the ISO 13485: 2016 standard (clause 7.5.9) details the identification and traceability requirements applicable to automated quality control systems.

The QCRx® aligns with these two standards: it timestamps the results, generates a PDF report that can be archived in the LIMS/DPI, thus providing a batch conformity certificate according to ISO 13485 requirements and ANSM GPP.

For oncological protocols (FOLFOX, FOLFIRI + folinic acid), the device also follows the recommendations published by the National Cancer Institute for the standardization of chemotherapy regimens.

They trust us

The reliability of the QCRx® is based on concrete field feedback. Today, cancer centers, including the Gustave-Roussy Institute and PHP, are validating their cytotoxic preparations with QCRx®.

Schedule an Oncology Demo

To experience the power of real-time analytical control for yourself, arrange a demonstration.

Our service includes training your healthcare professionals in the daily use of QCRx® as well as dedicated technical support.

Learn how QCRx® controls your pharmaceuticals in less than 70 seconds.

Sign up for an online demo.
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